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Updated: Feb 14, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

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Designing Scalable Mechano-Virucidal Nanostructured Acrylic Surfaces for Enhanced Viral Inactivation.

Samson W L Mah^1,2,3, Denver P Linklater^3,4,5, Vassil Tzanov⁶

¹School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|February 13, 2026

Summary

New nanostructured surfaces physically rupture viruses, offering a chemical-free antiviral solution. Dense nanopillar arrays show significant reduction in human parainfluenza virus type 3 infectivity within an hour.

Keywords:

antiviral nanostructured surfaces environmentally safe materials mechano‐virucidal effects nanoimprint lithography polymers scalable fabrication surface mechanics

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Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

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Published on: March 1, 2016

Area of Science:

Materials Science
Nanotechnology
Biophysics

Background:

Viral transmission via surfaces is a major public health issue.
Current antiviral coatings have limitations like cytotoxicity and resistance.
Nanostructured surfaces show promise for physical pathogen inactivation.

Purpose of the Study:

To develop and evaluate nanostructured surfaces as a mechano-virucidal platform.
To investigate the impact of nanopillar geometry on antiviral efficacy.
To explore a scalable, chemical-free approach to antiviral surface protection.

Main Methods:

Fabrication of flexible nanostructured acrylic films using AAO molds and UV-NIL.
Systematic variation of nanopillar pitch and height.
Antiviral efficacy testing against human parainfluenza virus type 3 (hPIV-3).
Finite element method (FEM) simulations to analyze mechanical stresses.

Main Results:

Dense nanopillar arrays (60 nm pitch) reduced hPIV-3 infectivity by up to 1.2-log (94%) in 1 hour.
Interpillar spacing was the primary factor determining antiviral effectiveness.
FEM simulations confirmed stresses exceeding the viral envelope rupture threshold.
Larger pitches (100 nm, 200 nm) showed reduced or abolished antiviral activity.

Conclusions:

Nanostructured surfaces offer a scalable, chemical-free mechano-virucidal strategy.
Optimized nanopillar spacing is crucial for effective physical virus inactivation.
This technology has potential applications in healthcare, consumer products, and environmental settings.