Related Experiment Video

Updated: Feb 14, 2026

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

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Ceritinib efficacy in SMARCA4-deficient NSCLC harboring novel CTNND2 ALK/EML4-ALK fusion: case report

Zhigang Fu1, Gengda Huang2, Jian Xie3

  • 1The Seventh Affiliated Hospital of Southern Medical University, Foshan, China.

Frontiers in Oncology
|February 13, 2026
PubMed

Insights

SMARCA4-deficient non-small cell lung cancer (SMARCA4-dNSCLC) with a rare double-gene fusion responded well to ALK inhibitor therapy. This genomic-guided treatment led to significant tumor regression and prolonged progression-free survival.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • SMARCA4-deficient non-small cell lung cancer (SMARCA4-dNSCLC) is aggressive with poor prognosis.
  • This subtype rarely presents with EGFR, ALK, or ROS1 alterations.
Keywords:
ALK double-fusionCTNND2-ALKNSCLCSMARCA4-dNSCLCceritinib

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