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Related Experiment Video

Updated: Feb 14, 2026

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

Relationship Between Nasal Trigeminal Receptor Expression and Trigeminal Sensitivity.

Akshita Joshi¹, Yiling Mai¹, Susanne Füssel²

¹Department of Otorhinolaryngology, Smell and Taste Clinic TU Dresden Dresden Germany.

|February 13, 2026

Summary

Assessing intranasal trigeminal function is vital. Lower TRPA1 mRNA expression in the nasal mucosa correlates with reduced trigeminal sensitivity, suggesting TRPA1 as a biomarker for nasal function.

Keywords:

intranasal trigeminal function lateralization task nasal swab trigeminal function measurement trigeminal receptor trigeminal sensitivity

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In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

Published on: August 1, 2025

Area of Science:

Neuroscience
Sensory Biology
Molecular Biology

Background:

Intact intranasal trigeminal function is essential for sensory perception and protective reflexes.
Transient receptor potential (TRP) channels mediate trigeminal nerve activation.
Assessing intranasal trigeminal function is crucial for understanding sensory processing.

Purpose of the Study:

To investigate the relationship between intranasal trigeminal sensitivity and TRP channel mRNA expression.
To determine if TRP channel expression levels can serve as objective indicators of trigeminal function.

Main Methods:

Quantitative polymerase chain reaction (qPCR) was used to measure TRP channel mRNA expression.
Intranasal trigeminal sensitivity was assessed using a lateralization task in healthy individuals.

Main Results:

Individuals with lower trigeminal sensitivity scores showed significantly reduced TRPA1 mRNA expression.
A correlation was found between TRPA1 mRNA levels and psychophysical measures of trigeminal function.

Conclusions:

TRPA1 expression in the nasal mucosa may influence behavioral responses to trigeminal stimulation.
Nasal TRPA1 mRNA levels show potential as a non-invasive biomarker for assessing intranasal trigeminal function.