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Updated: Feb 14, 2026

Brain Banking: Making the Most of your Research Specimens
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Brain banking for research: can we achieve efficient banking?

Irina Alafuzoff1,2, Björn Ersson1, Sylwia Libard1,2

  • 1Department of Pathology, Uppsala University Hospital, Uppsala, Sweden.

Frontiers in Neurology
|February 13, 2026
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Pathologists examine human tissue changes using microscopy and biobanks to understand organ dysfunction. This review highlights pathology

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Area of Science:

  • Pathology
  • Histopathology
  • Biomedical Research

Background:

  • Clinical and surgical pathologists investigate human tissue alterations, mass lesions, and organ dysfunction.
  • Traditional assessment involves macroscopic and microscopic examination (light and electron microscopy) comparing lesioned to normal tissue.
  • Pathology has historically described and named observed tissue abnormalities.

Purpose of the Study:

  • To summarize key aspects of work within the field of pathology.
  • To discuss the limitations of current pathological assessment methods.
  • To emphasize specific considerations within brain pathology.

Main Methods:

  • Review of established pathological diagnostic techniques.
  • Analysis of tissue sampling for biobank creation.
  • Examination of research applications utilizing biobanked tissues.

Main Results:

  • Tissue analysis via microscopy has been fundamental in understanding disease.
  • Biobanks, archives of analyzed and stored tissue samples, have enabled extensive research.
  • Knowledge of tissue alterations has grown exponentially due to these practices.

Conclusions:

  • Pathology relies on detailed tissue examination to explain disease.
  • Biobanks are crucial resources for advancing research in tissue pathology.
  • Continued research, particularly in brain pathology, is essential for further understanding.