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Metabolic reprogramming and immunosenescence: a new sight for glioma therapy

Huali Fan1,2, Shizhuo Yang1,2, Qing Lu1,2

  • 1Department of Pharmacy, West China Tianfu Hospital, Sichuan University, Chengdu, China.

Frontiers in Cell and Developmental Biology
|February 13, 2026
PubMed

Insights

Glioma treatment faces challenges due to the tumor microenvironment. This study explores how metabolic reprogramming and immunosenescence impact glioma progression and therapy resistance, offering potential therapeutic strategies.

Area of Science:

  • Neuro-oncology
  • Cancer Immunology
  • Metabolic Pathways

Background:

  • Gliomas are primary central nervous system tumors with poor prognosis and high recurrence.
  • The glioma microenvironment is immunosuppressive, hindering effective immunotherapy.
  • Metabolic reprogramming and immunosenescence are key hallmarks of glioma progression and therapy resistance.

Purpose of the Study:

  • To demonstrate the significance and function of metabolic reprogramming in gliomas.
  • To elucidate the role of immunosenescence in glioma pathogenesis.
  • To provide evidence for promising therapeutic strategies targeting these mechanisms.

Main Methods:

  • Review of current literature on glioma metabolism and immunosenescence.
  • Analysis of key metabolic alterations (Warburg effect, glutamine dependency, PPP, lipid metabolism).
  • Examination of immunosenescence components (immune dysregulation, SASP, epigenetic changes).

Main Results:

  • Metabolic reprogramming drives glioma progression and therapy resistance.
  • Immunosenescence contributes to immune cell dysfunction and an immunosuppressive microenvironment.
  • Interactions exist between senescent immune cells and the metabolic microenvironment, and vice versa.

Conclusions:

  • Metabolic reprogramming and immunosenescence are critical factors in glioma.
  • Understanding these processes is vital for developing novel glioma therapies.
  • Targeting metabolic and immune pathways holds promise for improving glioma treatment outcomes.
Keywords:
epigenetic regulationgliomaimmunosenescencemetabolic reprogrammingtumor microenvironment

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