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Lisinopril-Induced Angioedema Triggered by Tattoo Cellulitis and Acute Kidney Injury: A Case Report
Mechal Zedan1, Stephen Howard2, Preston Foryt3
1Internal Medicine, Lake Erie College of Osteopathic Medicine, Rochester, USA.
None:
Angiotensin-converting enzyme inhibitor-induced angioedema is a rare, potentially life-threatening disorder. This mostly manifests with swelling of the lips, tongue, and face with no known reports of angiotensin-converting enzyme inhibitor-induced angioedema from soft-tissue infections. We present herein a case of a 47-year-old male with a history of chronic kidney disease stage III who developed acute upper lip angioedema and severe acute kidney injury while on lisinopril/hydrochlorothiazide, following tattoo-related cellulitis. We propose that inflammatory activation from cellulitis amplified kallikrein-kinin system activity and bradykinin generation, precipitating angioedema in the setting of angiotensin-converting enzyme inhibition and transient renal dysfunction. This case highlights a rare but important intersection between infection-driven inflammation and angiotensin-converting enzyme inhibitor-induced angioedema.
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