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Related Experiment Video

Updated: Feb 14, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
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Transcatheter Tricuspid Valve Replacement: Current Evidence, Device Landscape, and Future Directions.

Ebrahim K Al-Ebrahim1, Tahir Mohamed2

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|February 13, 2026
PubMed
Summary

Transcatheter tricuspid valve replacement (TTVR) offers a new solution for severe tricuspid regurgitation (TR) when repair is not ideal. This approach effectively eliminates TR, addressing a significant unmet need in cardiac care.

Keywords:
tanscathetertricuspid valvetricuspid valve repairttvrvalve replacement

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Surgery

Background:

  • Severe tricuspid regurgitation (TR) affects a large population historically undertreated.
  • Transcatheter tricuspid valve interventions have advanced significantly in the past decade.
  • Orthotopic transcatheter tricuspid valve replacement (TTVR) is a key innovation for managing severe TR.

Purpose of the Study:

  • To review the epidemiology and pathophysiology of severe TR.
  • To discuss the rationale for TTVR.
  • To summarize contemporary TTVR devices, implantation techniques, clinical evidence, and future directions.

Main Methods:

  • This is a narrative review.
  • Literature search on transcatheter tricuspid valve interventions.
  • Synthesis of information on TTVR devices and clinical outcomes.

Main Results:

  • TTVR can achieve near-complete elimination of TR.
  • It is particularly effective in anatomies unsuitable for valve repair.
  • Contemporary devices and techniques are evolving rapidly.

Conclusions:

  • TTVR represents a transformative strategy for severe TR.
  • Further research is needed to address remaining challenges and optimize patient selection.
  • The field is rapidly advancing, offering new hope for patients with TR.