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Using Quality Improvement and Workflow Analysis to Successfully Implement Evidence-Based Interventions to Increase

Mark M Macauda1, Lisa A Scott1, Rebecca P Eaddy1

  • 1Colorectal Cancer Prevention Network at the University of South Carolina, Columbia, South Carolina, USA.

Cancer Medicine
|February 13, 2026
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Summary
This summary is machine-generated.

Implementing evidence-based interventions (EBIs) increased colorectal cancer (CRC) screening rates in primary care clinics. Tailored EBI selection positively impacted CRC screening, with variations based on clinic characteristics.

Keywords:
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Area of Science:

  • Public Health
  • Preventive Medicine
  • Health Services Research

Background:

  • Colorectal cancer (CRC) remains a significant cause of cancer mortality in the US, despite being preventable through timely screening.
  • Evidence-based interventions (EBIs) offer a promising strategy to enhance CRC screening rates.
  • Limited descriptive literature exists on the processes for assessing and implementing EBIs for CRC screening.

Purpose of the Study:

  • To describe the process of implementing EBIs to increase CRC screening in primary care settings.
  • To report changes in CRC screening rates following EBI implementation.
  • To examine the impact of these interventions across clinics with varying attributes.

Main Methods:

  • A quality improvement project involving 25 primary care clinics facilitated by the Colorectal Cancer Prevention Network (CCPN).
  • Chi-square tests were used to analyze changes in screening rates from baseline to years two and three.
  • Difference-in-Differences analysis assessed screening rate changes based on clinic attributes.

Main Results:

  • Overall CRC screening increased from 45% to 51% (p < 0.05) by the third year.
  • 16 out of 25 clinics showed increased screening in year two, and 14 in year three.
  • Clinics with smaller patient populations, rural locations, fewer uninsured patients, and lower baseline rates demonstrated greater improvements.

Conclusions:

  • A structured, tailored approach to selecting EBIs can positively influence CRC screening rates.
  • The effectiveness of interventions may vary depending on specific clinic characteristics.
  • Continuous quality improvement efforts are crucial for optimizing CRC screening in diverse primary care settings.