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MYDGF Governs Endothelial Homeostasis in Hypertension.
Min Liu1, Xiaohan Liu1, Ping Zhan1
1Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China (M.L., X.L., P.Z., H.J., J.W., C.G., Z.W., X.W., W.T., F.Y.).
Hypertension (Dallas, Tex. : 1979)
|February 13, 2026
Summary
Myeloid-derived growth factor (MYDGF) deficiency worsens hypertension-induced endothelial dysfunction. Restoring MYDGF levels protects against cardiovascular and renal injury by maintaining endothelial homeostasis via HMOX1 regulation.
Area of Science:
- Cardiovascular Biology
- Endothelial Function
- Hypertension Research
Background:
- Endothelial dysfunction is a key factor in hypertension and related organ damage.
- Myeloid-derived growth factor (MYDGF) is expressed in various cells, but its role in endothelial cells during hypertension is unknown.
Purpose of the Study:
- To investigate the role of endothelial MYDGF in hypertension and associated cardiovascular/renal injury.
Main Methods:
- Utilized endothelial-specific knockout of MYDGF mice.
- Administered recombinant MYDGF for therapeutic assessment.
Main Results:
- Endothelial MYDGF expression decreased in hypertensive mice.
- MYDGF deficiency exacerbated endothelial dysfunction and organ injury, while MYDGF restoration or administration attenuated these effects.
- MYDGF demonstrated protective functions including anti-inflammation, anti-apoptosis, reduced permeability, and NO generation.
Conclusions:
- MYDGF is crucial for maintaining endothelial homeostasis in hypertension by regulating HMOX1.
- Targeting MYDGF presents a novel therapeutic strategy for hypertension and its complications.
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