[Metabolic dysfunction-associated steatotic liver disease may affect the brain].

Area of Science:

• Hepatology
• Neurology
• Metabolic Disorders

Background:

• Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition affecting a significant portion of the global population.
• Emerging evidence indicates a strong association between MASLD and cognitive impairment, even in its nascent stages.
• The pathophysiology is thought to involve systemic inflammation, cerebrovascular issues, and accelerated brain aging.

Purpose of the Study:

• To review the current understanding of the relationship between MASLD and cognitive dysfunction.
• To explore the proposed mechanisms linking MASLD to brain health.
• To identify the need for further clinical research in diagnosing cognitive issues in MASLD patients.

Main Methods:

• Literature review of recent studies on MASLD and cognitive function.
• Analysis of proposed pathophysiological pathways.
• Identification of gaps in current diagnostic approaches.

Main Results:

• MASLD is increasingly recognized as a factor contributing to cognitive dysfunction.
• Systemic inflammation, cerebrovascular dysfunction, and premature brain aging are key proposed mechanisms.
• Optimal diagnostic tools for cognitive impairment in MASLD are yet to be established.

Conclusions:

• MASLD poses a risk for cognitive dysfunction through multiple interconnected pathways.
• Further clinical investigation is crucial for developing effective diagnostic strategies.
• Early identification and management of cognitive issues in MASLD patients are warranted.