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Updated: Feb 14, 2026

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice
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A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice

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Association of Rotavirus Infection With Biliary Atresia: A Retrospective Comparative Analysis of Virus-Specific

Yoshiki Kawamura1, Masaru Ihira2, Yuki Higashimoto3

  • 1Department of Pediatrics, Fujita health University School of Medicine, Toyoake, Japan.

Journal of Medical Virology
|February 13, 2026
PubMed

Insights

Infants with biliary atresia (BA) show higher rotavirus (RV) immunoglobulin A (IgA) levels, suggesting a potential link between RV infection and BA. Further research is needed to confirm this association and its implications for infant health.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Infectious Diseases

Background:

  • Biliary atresia (BA) is a severe infantile liver disease with unknown causes.
  • Rotavirus (RV) infection is suspected in BA pathogenesis, but human evidence is limited.
  • This study examines serological markers of recent RV infection in infants with BA.

Purpose of the Study:

  • To investigate the association between rotavirus (RV) infection and biliary atresia (BA) in infants.
  • To assess the presence of RV-specific immunoglobulin A (IgA) as a marker of primary RV infection.
  • To compare RV-IgA levels in infants with BA versus healthy controls.

Main Methods:

  • Retrospective analysis of serum samples from 17 infants with BA and 30 controls.
  • Enzyme-linked immunosorbent assay (ELISA) to detect anti-RV-IgA titers.
  • Commercial immunoassays for Cytomegalovirus (CMV)-IgM and Epstein-Barr virus (EBV)-VCA-IgM.

Main Results:

  • RV-IgA was detected in 70.6% of BA patients vs. 3.4% of controls (p < 0.001).
  • Significantly higher RV-IgA titers were observed in the BA group compared to controls (p = 0.004).
  • 84.6% of BA patients diagnosed after 14 days of age were RV-IgA-positive.

Conclusions:

  • Findings suggest a potential association between rotavirus infection and biliary atresia pathogenesis.
  • The lack of BA reduction post-RV vaccine introduction necessitates cautious interpretation.
  • Prospective multicenter studies are required to establish a causal role for RV in BA.
Abstract

Keywords:
ELISAIgAbiliary atresiarotavirusserology

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