Related Experiment Video
Updated: Feb 14, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
21.7K
Relationship between vascular density and microenvironment in medullary thyroid carcinoma
Maria Eduarda de Castro1, Jean Ferrante Mariano1, Marina M L Kizys1
1Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Endocrine-Related Cancer
|February 13, 2026
Summary
Vascular density and immune cell infiltration vary across medullary thyroid carcinoma (MTC) regions. Elevated lymphatic vessel density in tumor centers correlates with metastasis, suggesting prognostic potential.
Area of Science:
- Oncology
- Immunology
- Vascular Biology
Background:
- Medullary thyroid carcinoma (MTC) exhibits complex tumor microenvironments.
- Understanding the interplay between vascularization and immune cells is crucial for MTC progression.
- Spatial heterogeneity in MTC's immune and vascular components remains underexplored.
Purpose of the Study:
- To investigate the relationship between vascular density and immune cell infiltration in MTC.
- To analyze spatial variations of these components within tumor regions (center, interface, normal tissue, metastases).
- To identify potential prognostic markers and therapeutic targets based on immuno-vascular interactions.
Main Methods:
- Tissue microarray (TMA) analysis of 24 MTC cases.
- Assessment of immune markers (macrophages, lymphocytes, T-regs) and vascular markers (lymphatic vessels, microvessels).
- Quantitative analysis using ImageJ and QuPath software for spatial distribution and correlation.
Main Results:
- Significant differences in vascular density across tumor regions were observed.
- Lymphatic vessel density (D2-40+) was higher in normal tissue than tumor centers but elevated in tumor centers of metastatic cases.
- Specific correlations found between vascular markers and immune cell infiltration (e.g., ERG+ vessels with mast cells, D2-40+ with CD8+ T-cells).
Conclusions:
- MTC displays distinct spatial heterogeneity in vascular architecture and immune cell distribution.
- Immuno-vascular interactions are region-specific and may influence MTC progression and metastasis.
- Elevated D2-40+ density in tumor centers is linked to metastasis, indicating potential prognostic value.
Keywords:
immune microenvironmentimmunohistochemistrymedullary thyroid carcinomamicrovessel densitytissue microarrayMore Related Videos
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