Related Experiment Video
Updated: Feb 14, 2026
10:07
Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
24.6K
Post‑translational modifications in diabetic kidney disease (Review).
Mengfei He1, Zihang Wang2, Zhuang Miao3
1Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
International Journal of Molecular Medicine
|February 13, 2026
Summary
Post-translational modifications (PTMs) are linked to diabetic kidney disease (DKD) progression. Understanding these protein changes is key to addressing DKD
Area of Science:
- Biochemistry
- Nephrology
- Molecular Biology
Background:
- Diabetic kidney disease (DKD) is a major cause of chronic kidney disease and kidney failure.
- DKD significantly increases the risk of cardiovascular events.
- Post-translational modifications (PTMs) diversify protein functions and are implicated in DKD.
Purpose of the Study:
- To review the role of various PTMs in DKD.
- To summarize PTMs involved in DKD pathophysiology.
- To highlight PTMs in DKD mechanisms like cell death, oxidative stress, inflammation, and fibrosis.
Main Methods:
- Literature review of PTMs in DKD.
- Analysis of PTMs' involvement in DKD pathogenesis.
- Synthesis of information on PTMs and DKD-related processes.
Main Results:
- PTMs, including phosphorylation, acetylation, and glycosylation, are associated with DKD.
- These modifications influence key DKD mechanisms.
- Specific PTMs like lactylation and neddylation are also relevant.
Conclusions:
- PTMs play a critical role in the development and progression of DKD.
- Targeting PTMs may offer therapeutic strategies for DKD.
- Further research into PTMs is essential for DKD management.
More Related Videos
10:12Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
Published on: April 21, 2023
3.7K
10:26Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
Published on: November 7, 2019
6.1K
Related Concept Videos
01:27Post-translational Translocation of Proteins to the RER
7.8K
A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
7.8K
01:25Chronic Kidney Disease I: Introduction
768
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
768
01:24Chronic Kidney Disease II: Clinical Manifestations
688
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
688
01:31Translation
157.3K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
157.3K
02:32Histone Modification
16.3K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.3K
01:10Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K