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Updated: Feb 14, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
Published on: March 6, 2013
Stability vs. activity in electrocatalytic hydrogen production and magnetic studies of mononuclear labile Cu(II) and
Maria A Bhatti1, Luca M Carrella1, Carsten Streb1
1Department Chemie, Johannes-Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. rentschl@uni-mainz.de.
Abstract:
In this study, two new mononuclear Schiff base salen-derived complexes, [CuII(H2LMe)]·1.5H2O (C1) and [NiII(H2LMe)]·3H2O (C2), were prepared from 2,6-bis(hydroxymethyl)-4-methylphenol H4L and characterised by single crystal X-ray diffractometry, infrared spectroscopy and elemental analysis. Electrochemical studies in DMF with acetic acid as a proton source revealed catalytic hydrogen evolution activity for both complexes, with C1 displaying higher activity, lower overpotential (η = 0.71 V), and a higher TOFmax of 452 029 s-1 compared to C2 (η = 0.89 V, TOFmax = 986 s-1). The stability of the compounds was tested via controlled potential electrolysis (CPE) and rinse tests, indicating partial heterogeneous contributions to catalysis from electrode-deposited species. These deposits were further analysed by SEM and EDX. To rule out the possibility of nanoparticle formation, dynamic light scattering DLS analysis was performed.
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