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Updated: Feb 14, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
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Asymmetrically Wetted Trilayer-Structured Wound Dressing with Unidirectional Moisture Transport and Hemostatic

Bo Wang1, Xinbo Ding1, Rui Huang1

  • 1College of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech University, Hangzhou 310018, China.

ACS Applied Bio Materials
|February 13, 2026
PubMed
Summary

A novel self-pumping Janus hemostatic dressing (Janus@BG5) utilizes a trilayered fibrous matrix for unidirectional moisture transport. This advanced wound dressing effectively manages exudates, inhibits bacterial colonization, and promotes hemostasis with no observed cytotoxicity.

Keywords:
hemostasishydrophilic−hydrophobic gradienttrilayered nanofibrous membraneunidirectional moisture transportwound dressing

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Area of Science:

  • Biomaterials Science
  • Wound Healing
  • Nanotechnology

Background:

  • Conventional wound dressings have limitations in exudate management due to poor draining capabilities.
  • Effective wound dressings require hemostatic properties, exudate absorption, and protection against infection and inflammation.

Purpose of the Study:

  • To develop a self-pumping Janus hemostatic dressing with unidirectional moisture transport for improved wound management.
  • To evaluate the hemostatic, antibacterial, and cytotoxic properties of the novel dressing.

Main Methods:

  • Fabrication of an electrospun trilayered fibrous matrix incorporating polylactic acid (PLA), silk fibroin (SF), and cerium-doped bioactive glass (Ce-BG@PDE) nanoparticles.
  • Characterization of the Janus@BG5 dressing's porosity, tensile strength, and unidirectional moisture transport.
  • Assessment of antibacterial activity against Escherichia coli and Staphylococcus aureus, hemostatic performance (blood absorption, clotting index, coagulation time), and in vitro cytotoxicity using human umbilical vein endothelial cells (HUVECs).

Main Results:

  • The Janus@BG5 dressing exhibited 88.0% porosity and 3.4 MPa tensile strength, demonstrating unidirectional moisture transport.
  • Significant inhibition of Escherichia coli (82.9 ± 2.7%) and Staphylococcus aureus (90.5 ± 0.7%) colonization was observed.
  • The dressing showed a high blood absorption rate (643.0%), a clotting index of 25.8%, and a coagulation time of 237.0 ± 10.5 s, with no cytotoxicity to HUVECs.

Conclusions:

  • The developed trilayered Janus nanofibrous membrane (Janus@BG5) effectively manages exudates and provides hemostatic and antibacterial functions.
  • The dressing's unique unidirectional moisture transport and biocompatibility suggest its potential for advanced wound dressing applications.