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Updated: Feb 14, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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CLK1 Promotes Myeloid-Derived Suppressor Cell Trafficking and Reprograms the Tumor Microenvironment by Activating

Peisi Li1,2,3,4,5, Yumo Xie1,2,3,4,5,6, Dawang Zhou7,8,9

  • 1Guangdong Institute of Gastroenterology, Guangzhou, China.

Cancer Immunology Research
|February 13, 2026
PubMed
Summary

Targeting CLK1 in colorectal cancer (CRC) reduces immunosuppressive myeloid-derived suppressor cells (MDSCs) and enhances T-cell activity. Combining CLK1 inhibition with anti-PD1 therapy boosts antitumor immunity, improving immunotherapy efficacy.

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