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Updated: Feb 14, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Selenium-Containing Compounds in Breast Cancer Therapy.

Elena G Varlamova1

  • 1Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", st. Institutskaya 3, Pushchino, 142290, Russia. 1928lv@mail.ru.

Biological Trace Element Research
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Selenium compounds show promise for breast cancer therapy, offering new avenues beyond traditional treatments. Research explores various selenium agents, including nanoparticles and proteins, for personalized medicine approaches.

Keywords:
Breast cancerInorganic selenium compoundsOrganic selenium compoundsSeleniumSelenium nanoparticles

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Area of Science:

  • Oncology
  • Materials Science
  • Nanotechnology

Background:

  • Breast cancer is a leading cause of female mortality, with drug resistance limiting current chemotherapy and radiation efficacy.
  • Personalized medicine approaches are crucial for advancing breast cancer treatment.
  • Selenium, an essential trace element, exhibits significant anticancer properties.

Purpose of the Study:

  • To review recent advancements in breast cancer therapy utilizing various selenium-containing agents.
  • To explore the therapeutic potential of inorganic and organic selenium compounds, nanoselenium, and selenoproteins.
  • To enhance understanding of the mechanisms behind selenium-based breast cancer treatment.

Main Methods:

  • Literature review of scientific papers on selenium-based agents in breast cancer therapy.
  • Analysis of studies focusing on inorganic and organic selenium compounds.
  • Examination of research on nanoselenium and selenoproteins for anticancer applications.

Main Results:

  • Selenium-based nanocomposites and complexes are actively researched for therapeutic anticancer properties.
  • Diverse selenium agents, including inorganic/organic compounds, nanoselenium, and selenoproteins, show potential in breast cancer treatment.
  • Recent studies highlight the evolving landscape of selenium's role in combating breast cancer.

Conclusions:

  • Selenium-containing agents represent a promising frontier in breast cancer therapy, aligning with personalized medicine goals.
  • Further research into selenium compounds and their mechanisms can refine breast cancer treatment strategies.
  • The review provides a comprehensive overview of selenium's application in advancing breast cancer care.