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Mechanism of RBM15 in Regulating PD-L1-Mediated Immune Escape in Ovarian Cancer Through the JAK2/STAT3/STAT5 Pathway

Chengju Zhang1, Tiantian Feng2, Hu Wang1

  • 1Department of Gynecology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.

Archivum Immunologiae Et Therapiae Experimentalis
|February 13, 2026
PubMed

Insights

RNA-binding motif protein 15 (RBM15) promotes immune escape in ovarian cancer by upregulating circFGFR3 and activating the JAK/STAT pathway. This finding offers a new immunotherapeutic strategy for ovarian cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Ovarian cancer (OC) exhibits immune escape mechanisms.
  • Programmed death-ligand 1 (PD-L1) plays a crucial role in tumor immune evasion.
  • Novel therapeutic targets are needed to overcome immune resistance in OC.

Purpose of the Study:

  • To investigate the role of RNA-binding motif protein 15 (RBM15) in PD-L1-mediated immune escape in OC.
  • To elucidate the molecular mechanisms by which RBM15 influences OC progression and immune evasion.
  • To identify potential immunotherapeutic targets for OC.

Main Methods:

  • Assessed RBM15, circFGFR3, JAK2, STAT3, and STAT5 expression in OC.
  • Analyzed OC cell progression and co-cultured OC cells with CD8+ T cells.
  • Determined m6A enrichment on circFGFR3 and investigated JAK/STAT pathway activation.
  • Analyzed molecular interactions between circFGFR3, EIF4A3, JAK2, STAT3, and STAT5.

Main Results:

  • RBM15 promotes PD-L1-mediated immune escape in OC.
  • RBM15 upregulates circFGFR3 expression via m6A modification.
  • RBM15 activates the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway, accelerating OC progression.
  • RBM15 promotes OC cell progression and immune escape.

Conclusions:

  • RBM15 is a key driver of immune escape and progression in ovarian cancer.
  • Targeting RBM15 or its downstream pathways (circFGFR3/JAK/STAT) may represent a novel immunotherapeutic strategy for OC.
  • Understanding the RBM15/circFGFR3/JAK/STAT axis provides insights into OC pathogenesis and treatment resistance.
Keywords:
Immune escapeOvarian cancerRBM15

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