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Updated: Feb 14, 2026

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
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Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

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Comparable Diagnostic Performance of 68 Ga-FAPI and 18 F-FDG PET/CT in Perineal Rhabdomyosarcoma

Sara Shakeri1, Amin Saber Tanha2, Farid Jafari Zarrin Ghabaei2

  • 1Department of Nuclear Medicine, Cancer Research Center, RAZAVI Hospital, Imam Reza International University.

Clinical Nuclear Medicine
|February 13, 2026
PubMed

Insights

This study shows that 68Ga-FAPI-46 PET/CT imaging is valuable for diagnosing pediatric rhabdomyosarcoma (RMS), offering better contrast than standard imaging for this rare soft tissue sarcoma.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Pediatric Imaging

Background:

  • Rhabdomyosarcoma (RMS) is a rare soft tissue sarcoma in children.
  • Accurate staging is crucial for effective treatment planning in pediatric RMS.
  • Standard imaging modalities may sometimes overlook primary tumors or metastases.

Purpose of the Study:

  • To evaluate the diagnostic utility of 68Ga-FAPI-46 PET/CT in a pediatric case of perineal rhabdomyosarcoma.
  • To compare FAP-targeted imaging with 18F-FDG PET/CT and contrast-enhanced CT for staging RMS.
  • To explore the potential theranostic role of FAPI imaging in soft tissue sarcomas.

Main Methods:

  • Case report of a 14-year-old male diagnosed with perineal RMS.
  • Initial staging utilized 18F-FDG PET/CT and contrast-enhanced CT.
  • A complementary 68Ga-FAPI-46 PET/CT scan was performed for further evaluation.

Main Results:

  • 18F-FDG PET/CT identified hypermetabolic lymph nodes but missed the primary perineal mass.
  • Contrast-enhanced CT also failed to detect the primary perineal tumor.
  • 68Ga-FAPI-46 PET/CT successfully detected the primary perineal RMS with superior target-to-background contrast.

Conclusions:

  • FAP-targeted imaging, specifically 68Ga-FAPI-46 PET/CT, demonstrates significant diagnostic value in pediatric RMS.
  • FAPI imaging offers improved visualization of the primary tumor compared to conventional methods.
  • This highlights the potential of FAPI as a theranostic agent in soft tissue sarcomas.
Keywords:
metastasis workuppediatric oncologyradioligand therapysoft tissue sarcomatheranostics

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