Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Declination01:19

Magnetic Declination

493
Magnetic declination is the angle between true north, which aligns with the Earth's rotational axis, and magnetic north, which follows the direction of the Earth's magnetic field. This discrepancy exists because the magnetic poles do not coincide with the geographic poles. The value of magnetic declination depends on the observer's location on Earth and is subject to changes over time due to the dynamic nature of the Earth's magnetic field.The declination is called eastern when magnetic north...
493
Conservation of Declining Populations02:07

Conservation of Declining Populations

13.4K
Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.
13.4K
Primary Active Transport01:47

Primary Active Transport

201.1K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
201.1K
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

60.7K
Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.7K
Primary Production01:06

Primary Production

25.6K
The total amount of energy acquired by primary producers in an ecosystem is called gross primary production (GPP). However, of this energy, producers use some for metabolic processes, and some is lost as heat, decreasing the amount of energy available to the next trophic level. The remaining usable amount of energy is called the net primary productivity (NPP). In terrestrial ecosystems, NPP is driven by climate, while light penetration and nutrient availability drive NPP in aquatic ecosystems.
25.6K
Primary Distribution01:28

Primary Distribution

556
Primary distribution systems deliver electrical power from substations to consumers through various voltage classes, with 15-kV class voltages being predominant among U.S. utilities. Older 2.5- and 5-kV classes are being replaced by 15-kV primaries, while higher 25- to 34.5-kV classes are used in high-density urban areas and rural regions with long feeders. Three-phase, four-wire multigrounded systems are widely employed for balanced power delivery, using the neutral wire as a grounding point.
556

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severity of Chronic Kidney Disease and Outcomes After Admission to the Intensive Care Unit.

JAMA network open·2026
Same author

Primary aldosteronism.

Nature reviews. Disease primers·2026
Same author

Atrial Fibrillation and Stroke Prevention and Management in Chronic Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Systematic Review and Meta-Analysis of Intensive Care Unit Scoring Systems' Performance in Patients with Pre-Existing Kidney Disease.

Kidney international reports·2026
Same author

Eating disorder-related electrolyte abnormalities and adverse outcomes: A systematic review and meta-analysis.

PloS one·2026
Same author

Agreement Between Molecular Imaging and Adrenal Vein Sampling for Localization in Primary Aldosteronism: A Systematic Review.

Journal of the American Heart Association·2026
Same journal

Parathyroid Hormone Receptor 1 Facilitates Cyst Growth in Genetic Models of Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Alanyl-tRNA Synthetase 1 and Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Evaluating Barriers to Kidney Transplantation in the United States.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Comparing Catheters to Fistulas in Older Patients Starting Hemodialysis (ACCESS HD).

Journal of the American Society of Nephrology : JASN·2026
Same journal

Impact of Cooked Meat or Fish Ingestion on Creatinine Generation Rate, Serum Creatinine, and Estimated Glomerular Filtration Rate.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Smooth Muscle Cell-Specific Expression of Cyclic Nucleotide Phosphodiesterase 10a Promotes the Development of Medial Artery Calcification.

Journal of the American Society of Nephrology : JASN·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

3.4K

Subclinical Primary Aldosteronism and eGFR Decline Over Time.

Gregory L Hundemer1,2, Louis-Charles Desbiens3, Mohsen Agharazii4,5

  • 1Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Journal of the American Society of Nephrology : JASN
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

Subclinical primary aldosteronism, indicated by elevated aldosterone-to-renin ratio (ARR), is linked to faster kidney function decline. Lower renin levels also correlate with increased estimated glomerular filtration rate (eGFR) decline, independent of blood pressure.

Keywords:
BPCKDaldosteronehypertensionkidney disease

More Related Videos

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.7K
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.3K

Related Experiment Videos

Last Updated: Feb 15, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

3.4K
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.7K
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.3K

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Research

Background:

  • Primary aldosteronism accelerates kidney function decline.
  • Subclinical forms of primary aldosteronism are common but their impact on kidney function is unknown.

Purpose of the Study:

  • To investigate the association between subclinical primary aldosteronism markers and estimated glomerular filtration rate (eGFR) decline.

Main Methods:

  • Prospective cohort study of 976 Canadian adults (40-69 years).
  • Measured aldosterone, renin, creatinine, and cystatin C.
  • Used multivariable linear mixed regression to assess associations of aldosterone, renin, and aldosterone-to-renin ratio (ARR) with eGFR decline over 5-7 years.

Main Results:

  • Higher ARR was associated with a 11% steeper eGFR decline over time.
  • Lower renin levels were associated with a 16% steeper eGFR decline over time.
  • Aldosterone alone showed no significant association with eGFR change.

Conclusions:

  • Elevated ARR and suppressed renin are independently associated with accelerated eGFR decline.
  • These associations persist regardless of blood pressure levels.