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Updated: Feb 15, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Triglycerides play a crucial role in the pathway from depression to cardiomyopathy: A mediation Mendelian

Boyang Sheng1, Shina Zhang1, Yuan Gao1,2

  • 1Department of Chinese Medicine Diagnosis, School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan Province, China.

Medicine
|February 13, 2026
PubMed

Insights

Depression increases triglyceride levels, raising the risk for dilated cardiomyopathy (DCM) and ischemic heart disease (IHD). Triglycerides fully mediate the depression-DCM link and partially mediate the depression-IHD connection.

Area of Science:

  • Cardiovascular Epidemiology
  • Psychiatric Genetics
  • Metabolic Disorders

Background:

  • The interplay between depression, hypertriglyceridemia, and cardiomyopathy (including ischemic heart disease and dilated cardiomyopathy) is not fully understood.
  • Investigating these causal pathways is crucial for understanding cardiovascular disease etiology.

Purpose of the Study:

  • To elucidate the causal relationships between depression, hypertriglyceridemia, and the development of cardiomyopathy.
  • To determine the mediating role of triglyceride levels in the association between depression and heart conditions.

Main Methods:

  • Utilized Mendelian randomization (MR) analyses with various methods (IVW, MR-Egger, weighted median) to assess causality.
  • Employed stepwise testing and multivariable MR for mediation analyses.

Main Results:

  • Depression onset elevates triglyceride levels, increasing the risk for dilated cardiomyopathy (DCM).
  • Depression directly increases ischemic heart disease (IHD) risk and indirectly via elevated triglycerides.
  • Elevated triglycerides significantly increase the risk for both IHD and DCM.
  • Triglycerides mediated 100% of the causal effect between depression and DCM, and 8.4% between depression and IHD.

Conclusions:

  • Depression is a significant risk factor for hypertriglyceridemia, which in turn contributes to cardiomyopathy development.
  • Triglyceride-lowering interventions may be beneficial in mitigating cardiovascular risks associated with depression.

Keywords:
Mendelian randomizationdepressiondilated cardiomyopathyischaemic heart diseasetriglycerides

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