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Lymph nodes-targeted nano-prodrug for precise B cell immunoregulation to prevent collagen-induced arthritis

Ning Li1, Wenlong Huang2, Zhaoshun Wu1

  • 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Road, Shanghai 200032, China; Spine Institute, Shanghai University of Traditional Chinese Medicine, 725 Wan-Ping South Road, Shanghai 200032, China.

Biomaterials
|February 13, 2026
PubMed

Insights

Preventing rheumatoid arthritis (RA) in its early stages is crucial. A new nano-prodrug (HC-IBR) targets B cells in lymph nodes, offering a potential strategy for RA prevention and reducing joint inflammation.

Area of Science:

  • Immunology
  • Nanotechnology
  • Drug Delivery

Background:

  • Rheumatoid arthritis (RA) is a systemic autoimmune disease causing irreversible joint destruction.
  • Early prevention of RA could significantly reduce incidence and disability.
  • Current RA prevention strategies lack sufficient focus on preclinical intervention.

Purpose of the Study:

  • To develop a novel nano-prodrug delivery system (HC-IBR) for preclinical RA intervention.
  • To modulate B cell immune responses in lymph nodes (LNs) during the preclinical phase of RA.
  • To investigate the efficacy of HC-IBR in controlling joint inflammation.

Main Methods:

  • Constructed HC-IBR via self-assembly of hyaluronic acid (HA) with cyanine7 (Cy7) and ibrutinib (IBR).
  • Evaluated HC-IBR targeting and accumulation in LNs.
  • Assessed light-controlled drug release and inhibition of B cell activity in a collagen-induced arthritis mouse model.

Main Results:

  • HC-IBR demonstrated effective targeting and accumulation in LNs.
  • Light irradiation controlled the release of IBR from HC-IBR.
  • HC-IBR combined with laser therapy significantly inhibited antigen-presenting B cells and germinal centers.
  • This approach effectively controlled joint inflammation in mice with collagen-induced arthritis.

Conclusions:

  • HC-IBR provides a precise and localized B cell immunoregulation strategy for RA prevention.
  • This nano-prodrug delivery system shows potential for preclinical intervention in rheumatoid arthritis.
  • Targeting B cell immune responses in LNs is a promising avenue for RA prevention.
Keywords:
B cellIbrutinibLymph nodes-targeted nano-prodrugRheumatoid arthritis prevention and treatment

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