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Auricular stimulation therapy: An evidence-based practice strategy for depression.

Jin Gao1, Yulong Liang2, Peijing Rong3

  • 1Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210000, China; The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210000, China.

Current Opinion in Pharmacology
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Auricular stimulation therapy (AST), including auricular vagus nerve stimulation and acupuncture, effectively treats depression. This non-drug approach offers comparable results to antidepressants with better tolerability and potential for reduced medication dosage.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Integrative Medicine

Background:

  • Depressive disorders represent a significant global health burden.
  • Current treatments, including antidepressants, have limitations in efficacy and tolerability.
  • Non-pharmacological interventions are increasingly sought for depression management.

Purpose of the Study:

  • To systematically review the evidence for Auricular Stimulation Therapy (AST) in treating depressive disorders.
  • To evaluate the efficacy and safety of AST compared to standard treatments.
  • To explore AST's potential as a medication-sparing strategy.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) and meta-analyses.
  • Inclusion of studies on transcutaneous auricular vagus nerve stimulation (taVNS) and auricular acupuncture.
  • Analysis of symptom reduction, tolerability, and functional outcomes.

Main Results:

  • AST demonstrates significant efficacy in reducing symptoms across various depressive disorders, including postpartum depression (PPD) and post-stroke depression (PSD).
  • Treatment effects are comparable to first-line antidepressants.
  • AST exhibits a superior tolerability profile and is associated with improved sleep and cognitive function.

Conclusions:

  • Auricular stimulation therapy is a safe and effective non-pharmacological option for depression.
  • AST shows promise as an adjunct therapy to potentially reduce antidepressant dosage.
  • Further research should explore AST's long-term effects and integration into clinical practice.