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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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Polynomial division is an essential algebraic process to simplify expressions and solve equations. Just as numerical division separates a number into quotient and remainder, polynomial long division partitions a polynomial into simpler components; in this context, the dividend is the polynomial being divided, the divisor is the expression dividing it, and the result is expressed in terms of a quotient and a remainder.The division begins by arranging the dividend and divisor in standard...
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The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
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Related Experiment Video

Updated: Feb 15, 2026

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
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DAPK1 orchestrates cell division and junction to control corneal epithelial development.

Mulin Yang1, Zihe Zhao1, Weiwen Bu2

  • 1Department of Genetics and Cell Biology, College of Life Sciences, Tianjin Key Laboratory of Protein Science, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.

European Journal of Cell Biology
|February 13, 2026
PubMed
Summary

Death-associated protein kinase 1 (DAPK1) is crucial for healthy corneal development. Its absence causes corneal opacity and abnormal epithelial thickening, highlighting DAPK1 as a therapeutic target for eye diseases.

Keywords:
Cell divisionCell junctionCorneal epitheliumKnockout mouseStratification

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Last Updated: Feb 15, 2026

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Developmental Biology

Background:

  • Corneal epithelial stratification is essential for eye protection.
  • The molecular mechanisms governing this process remain incompletely understood.
  • Death-associated protein kinase 1 (DAPK1) is implicated in cellular processes.

Purpose of the Study:

  • To investigate the role of DAPK1 in corneal epithelial development.
  • To elucidate the molecular mechanisms by which DAPK1 influences corneal stratification.
  • To assess the therapeutic potential of DAPK1 in corneal diseases.

Main Methods:

  • Utilized Dapk1 knockout mouse models.
  • Performed immunofluorescence staining with epithelial-specific markers.
  • Analyzed corneal histology and cell junction integrity.

Main Results:

  • DAPK1 is upregulated during corneal epithelial development.
  • DAPK1 deficiency leads to corneal opacity and epithelial thickening.
  • DAPK1 loss disrupts stratification, impairs cell junctions, and causes epidermal-like changes.

Conclusions:

  • DAPK1 plays a critical role in regulating corneal epithelial stratification and development.
  • DAPK1 deficiency results in pathological changes mimicking epidermal development.
  • DAPK1 represents a potential therapeutic target for treating corneal diseases.