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5-oxo-5H-benzo[e]indole, a new type of highly sarcomagenic lactone
Science (New York, N.Y.)
|October 20, 1967
Abstract:
The title compound, which belongs to a new synthetic group of polycyclic lactones derived from isocoumarin, exhibits a remarkably high degree of carcinogenicity in situ when injected in mice. Cancer-inducing activity has also been found in similar isocoumarins, a family known to include many naturally occurring substances.