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Updated: Feb 15, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

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Pt(II) and Pd(II) complexes bearing 1,10-phenanthroline-based ligands: Distinct binding modes to DNA and anticancer

Misaki Nakai1, Yusuke Tsutsumi1, Togo Imai1

  • 1Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35, Yamatecho, Suita-shi, Osaka 564-8680, Japan.

Journal of Inorganic Biochemistry
|February 13, 2026
PubMed
Summary

Platinum and palladium complexes with phenanthroline ligands show distinct DNA interactions and anticancer activities. Palladium complexes exhibit strong cytotoxicity, while a specific platinum complex shows promise against cisplatin-resistant lung cancer.

Keywords:
AnticancerBovine serum albuminDNA interactionIntercalatorPalladiumPlatinum

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