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Updated: Feb 15, 2026
11:47
Regular Care and Maintenance of a Zebrafish Danio rerio Laboratory: An Introduction
Published on: November 18, 2012
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DANIO RERIO (ZEBRAFISH) - A UNIQUE AND INTEGRATIVE PLATFORM FOR 21ST CENTURY BIOMEDICAL RESEARCH
N Virina1, L Kuchieva1, Y Baturina1
1Saint-Petersburg State Pediatric Medical University; NWSMU named after I.I. Mechnikova, Saint-Petersburg, Russia. Military Medical Academy named after S. M. Kirov, Saint-Petersburg, Russia.
Georgian Medical News
|February 13, 2026
Summary
Zebrafish (Danio rerio) are valuable vertebrate models in biomedical research due to their genetic similarity to humans and ease of study. These fish accelerate preclinical research in areas like toxicology, oncology, and drug discovery, aiding translational medicine.
Area of Science:
- Biomedical Research
- Translational Medicine
- Vertebrate Models
Background:
- Zebrafish (Danio rerio) offer genetic similarity to humans, rapid development, and suitability for in vivo studies.
- Key features include optical transparency, high fecundity, and ease of genetic manipulation for detailed investigation.
- These characteristics make zebrafish ideal for studying developmental processes, disease mechanisms, and drug effects.
Purpose of the Study:
- To review the diverse applications of zebrafish in preclinical research.
- To highlight their utility in toxicology, neurobiology, oncology, regenerative medicine, infectious diseases, and drug discovery.
- To emphasize their role in accelerating translational medicine.
Main Methods:
- Review of current literature on zebrafish applications in preclinical research.
- Summarization of studies utilizing zebrafish for disease modeling and drug screening.
- Analysis of zebrafish's contribution to understanding molecular pathways and regenerative processes.
Main Results:
- Zebrafish models facilitate efficient screening of therapeutic compounds and real-time observation of diseases.
- They enable analysis of molecular pathways in tissue regeneration and disease progression.
- Zebrafish research significantly contributes to advancing preclinical studies and drug discovery.
Conclusions:
- Zebrafish provide a cost-effective and ethically advantageous research platform complementing mammalian models.
- Despite physiological differences, they are crucial for early-stage translational medicine.
- Continued use of zebrafish models accelerates biomedical research and therapeutic development.
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