Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stereotypes, Prejudice, and Discrimination02:55

Stereotypes, Prejudice, and Discrimination

95.5K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
95.5K
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

364
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
364
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

342
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
342
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

542
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
542
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

288
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
288
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

590
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
590

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of a high fat/sugar diet on morphine-stimulus control: implications for dysregulated drug intake.

Physiology & behavior·2026
Same author

Eutylone history selectively impacts the rewarding and aversive effects of cocaine, MDMA, and eutylone in female Sprague-Dawley rats.

Pharmacology, biochemistry, and behavior·2026
Same author

The therapeutic use of psychedelic drugs: Legal, policy, and neuroscientific perspectives.

Pharmacology, biochemistry, and behavior·2025
Same author

Control by food deprivation cues interferes with the ability to learn drug state cues in male and female Sprague-Dawley rats.

Physiology & behavior·2025
Same author

Oxidative Stress in HIV-Associated Neurodegeneration: Mechanisms of Pathogenesis and Therapeutic Targets.

International journal of molecular sciences·2025
Same author

Short-term effects of liraglutide and semaglutide on weight gain and adiposity by rats fed a Western diet.

Physiology & behavior·2025
Same journal

Prenatal Exposure to High- but Not Low-Molecular-Weight Poly(I:C) Produces Selective Sociability Deficits in Offspring.

Behavioural brain research·2026
Same journal

Understanding vulnerability through variability: a longitudinal twin study linking sex differences in neurodiversity, neurodevelopment and X-linked genetic mechanisms.

Behavioural brain research·2026
Same journal

Hippocampal plasticity predicts behavioral lateralization and stress resilience in laying hen chicks.

Behavioural brain research·2026
Same journal

Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats.

Behavioural brain research·2026
Same journal

Bacopa-enriched formulation enhances memory and synaptic plasticity in a rat model of vascular dementia.

Behavioural brain research·2026
Same journal

Prior exposure to methylphenidate attenuates ethanol-induced conditioned place preference in zebrafish.

Behavioural brain research·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Testing for Odor Discrimination and Habituation in Mice
06:41

Testing for Odor Discrimination and Habituation in Mice

Published on: May 5, 2015

18.9K

Concurrent Serial Feature Negative and Simple Discrimination Training and Testing in the Mouse.

Negar Ghasem Ardabili1, Jordyn Pettiford2, Alexia Hyde3

  • 1Department of Neuroscience, American University, Washington, DC 20016, United States; Psychopharmacology Laboratory, American University, Washington, DC 20016, United States; Center for Neuroscience and Behavior, American University, Washington, DC 20016, United States.

Behavioural Brain Research
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

Mice can solve complex serial feature negative (serFN) learning tasks, similar to rats. This learning may involve hippocampal-dependent modulatory inhibition, offering new tools for memory research.

Keywords:
CocaineInhibitory learningMiceWestern diet

More Related Videos

The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage
11:16

The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage

Published on: January 4, 2013

14.1K
Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.9K

Related Experiment Videos

Last Updated: Feb 15, 2026

Testing for Odor Discrimination and Habituation in Mice
06:41

Testing for Odor Discrimination and Habituation in Mice

Published on: May 5, 2015

18.9K
The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage
11:16

The Dig Task: A Simple Scent Discrimination Reveals Deficits Following Frontal Brain Damage

Published on: January 4, 2013

14.1K
Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.9K

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Cognitive Psychology

Background:

  • Rats solve serial feature negative (serFN) and simple discrimination (SD) problems concurrently.
  • serFN problem-solving in rats relies on the hippocampus, while SD does not.
  • Investigating serFN problem-solving in mice could expand research tools for hippocampal function.

Purpose of the Study:

  • To determine if mice can solve the serFN problem.
  • To investigate if mice solve serFN using hippocampal-dependent inhibitory modulation, like rats.
  • To assess the impact of pharmacological and dietary challenges on serFN and SD performance in mice.

Main Methods:

  • Mice were concurrently trained on serFN and SD tasks.
  • Experiment 1 involved cocaine administration post-training.
  • Experiment 2 involved exposure to a Western-style diet post-training.
  • Summation and retardation tests were used to analyze inhibitory mechanisms.

Main Results:

  • Mice successfully acquired both serFN and SD discriminations.
  • Cocaine administration did not impair performance on either task.
  • Western diet selectively impaired serFN performance, not SD performance.
  • Inhibitory control appeared modulatory, not direct, for serFN performance.

Conclusions:

  • Mice demonstrate the capacity to solve serFN discrimination tasks.
  • The learning mechanism for serFN in mice involves modulatory inhibitory control.
  • Findings suggest potential hippocampal mediation, aligning with rat models and enhancing research flexibility.