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Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
[Research advances in immunotherapy for gastric cancer with specific molecular subtypes]
1The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730030, China Department of General Surgery, the 940th Hospital of Joint Logistics Support Force of People's Liberation Army, Lanzhou 730050, China.
Abstract:
Gastric cancer is one of the most common malignant tumors. Immunotherapy has played a significant role in the neoadjuvant, conversion, and postoperative adjuvant treatment of gastric cancer. In recent years, immunotherapies such as immune checkpoint inhibitors, adoptive cell therapy, and antitumor vaccines have profoundly transformed the therapeutic landscape of gastric cancer. This review explores recent research progress in immunotherapy for gastric cancer with specific molecular subtypes, including HER2-positive, Claudin18.2-positive, dMMR/MSI-H, Epstein-Barr virus (EBV)-positive, and alpha-fetoprotein (AFP)-positive subtypes. The aim is to provide insights for developing personalized and precise treatment strategies for gastric cancer patients with different molecular subtypes and clinical stages.
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