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Efficacy of Microneedle Fractional Radiofrequency Combined With Platelet-Rich Plasma for the Treatment of Melasma: A

Ziyan Chen1, Yuhao Li1, Yi Ou1

  • 1Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Journal of Cosmetic Dermatology
|February 14, 2026
PubMed
Abstract

Insights

Microneedle fractional radiofrequency (MFR) effectively treats melasma. Adding platelet-rich plasma (PRP) to MFR did not significantly improve overall pigment scores but showed benefits in specific skin features.

Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Regenerative Medicine

Background:

  • Melasma is a common pigmentary disorder impacting quality of life.
  • Current melasma treatments have limitations in efficacy and relapse rates.
  • Microneedle fractional radiofrequency (MFR) and platelet-rich plasma (PRP) show potential for melasma treatment.

Purpose of the Study:

  • To compare the efficacy and safety of MFR combined with PRP versus MFR alone for facial melasma.
  • To evaluate treatment outcomes using clinical scores, skin analysis, and ultrasound measurements.

Main Methods:

  • A prospective, randomized, evaluator-blinded, split-face trial involving 30 patients with melasma.
  • Two sessions of MFR were administered, with one side receiving adjunctive PRP and the other receiving saline.
  • Outcomes assessed included mMASI scores, VISIA skin analysis, patient satisfaction, and ultrasound-measured skin thickness.

Main Results:

  • Both MFR with PRP and MFR alone reduced melasma severity scores.
  • VISIA analysis revealed significant improvements in red and brown spot scores on the MFR+PRP side.
  • Ultrasound showed increased dermal thickness on both sides, with no significant difference between treatments.

Conclusions:

  • MFR is an effective and safe treatment for melasma in Fitzpatrick skin types III-IV.
  • Adjunctive PRP did not enhance overall pigment scores or structural changes compared to MFR alone.
  • PRP may offer additional benefits for specific erythematous and pigmentary aspects of melasma.
Keywords:
melasmamicroneedle fractional radiofrequencyplatelet‐rich plasmaultrasound

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