Related Experiment Video
Updated: Feb 15, 2026
11:24
Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
Published on: October 18, 2011
15.2K
The correlation between YTHDF1 gene polymorphism and cognitive dysfunction after radiotherapy for glioma.
Huanfeng Zhu1, Xiyun Shi1,2, Dan Zong1
1Department of Radiation Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
The International Journal of Neuroscience
|February 14, 2026
Summary
YTHDF1 overexpression is linked to cognitive dysfunction after glioma radiotherapy. The rs6090311 G allele in YTHDF1 may offer protection against this common side effect in glioma patients.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Genetics
Background:
- Gliomas represent the most frequent primary malignant brain tumors.
- YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) plays a critical role in glioma treatment response.
- Understanding genetic factors influencing treatment side effects like cognitive dysfunction is crucial.
Purpose of the Study:
- To investigate the association between YTHDF1 single nucleotide polymorphisms (SNPs) and cognitive dysfunction after glioma radiotherapy.
- To explore the potential of YTHDF1 genetic variations as biomarkers for predicting treatment outcomes.
Main Methods:
- A cohort of 323 glioma patients was studied before and 3 months after radiotherapy.
- YTHDF1 mRNA expression was quantified using RT-qPCR.
- Four YTHDF1 SNPs were genotyped, and their association with cognitive dysfunction was analyzed using multivariate logistic regression.
Main Results:
- Elevated YTHDF1 mRNA expression was observed in patients with cognitive dysfunction (CD group).
- The YTHDF1 SNP rs6090311 showed significant differences in genotype and allele frequencies between CD and non-CD groups.
- Carriers of the rs6090311 G allele had a significantly reduced risk of developing post-radiotherapy cognitive dysfunction (OR = 0.319).
Conclusions:
- YTHDF1 overexpression is associated with cognitive dysfunction following glioma radiotherapy.
- The rs6090311 G allele of YTHDF1 may serve as a protective genetic marker against post-radiotherapy cognitive dysfunction in glioma patients.
Related Concept Videos
02:20Correlations
36.6K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.6K
01:27Correlation and Causation
43.0K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
43.0K
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
01:09Correlation
15.2K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
15.2K
01:05Single Nucleotide Polymorphisms-SNPs
18.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.6K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
755
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
755