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Predictors of USMLE Step 2 performance.

Mandeep Kaur1, Matthew Y C Lin2, Adnan Alseidi2,3

  • 1University of California San Francisco School of Medicine, San Francisco, CA, United States.

Academic Medicine : Journal of the Association of American Medical Colleges
|February 14, 2026
PubMed
Summary
This summary is machine-generated.

With USMLE Step 1 now pass/fail, prior standardized test scores like the MCAT and NBME subject exams predict USMLE Step 2 CK performance. Surgery, neurology, and psychiatry NBME exams are key predictors.

Keywords:
NBMEUnited States Medical Licensing Exam Step 2licensure or certification issuesstandardized testingundergraduate medical education

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Area of Science:

  • Medical Education
  • Standardized Testing
  • Medical Licensing Examinations

Background:

  • United States Medical Licensing Examination (USMLE) Step 2 Clinical Knowledge (CK) scores predict in-training exam performance.
  • USMLE Step 1 transitioned to pass/fail grading in 2022.
  • Identifying predictors for Step 2 CK is crucial for medical student assessment.

Purpose of the Study:

  • To identify factors predicting USMLE Step 2 CK scores.
  • To compare the predictive power of prior standardized test scores.
  • To inform interventions for students potentially underperforming.

Main Methods:

  • Cross-sectional study of 600 medical students (UCSF, matriculated 2016-2019).
  • Collected scores for Medical College Admission Test (MCAT), Comprehensive Basic Sciences Examination (CBSE), in-house block exams (OEQ), and National Board of Medical Examiners (NBME) subject exams.
  • Utilized multivariable regression models to assess score predictability.

Main Results:

  • A model including MCAT percentile, CBSE scores, NBME subject exams (neurology, psychiatry, surgery), and in-house block exams explained 45% of Step 2 CK score variability.
  • NBME subject exams in surgery demonstrated the strongest predictive value (β = 0.212, P < .001).
  • Neurology, psychiatry, and surgery NBME exam scores emerged as the most significant predictors of Step 2 performance.

Conclusions:

  • Prior standardized test performance, particularly NBME subject exams, predicts USMLE Step 2 CK scores.
  • Findings support early interventions for underperforming students.
  • Optimizing test scores enhances residency match success alongside a strong curriculum vitae.