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Artificial intelligence-enabled precision medicine for inflammatory skin diseases

Alice S Tang1, Maria L Wei2, Anna Haemel3

  • 1Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA.

The Journal of Investigative Dermatology
|February 14, 2026
PubMed

Recent advances in artificial intelligence (AI) and multimodal data collection are revolutionizing dermatology. Generative AI and machine-learning approaches offer opportunities to enhance the diagnosis and treatment of autoimmune and inflammatory skin diseases, including atopic dermatitis, psoriasis, hidradenitis suppurativa, vitiligo, alopecia areata, and rheumatic skin disease. This review examines the current landscape of AI applications for inflammatory skin diseases and explores how generative AI and machine-learning methods can advance the field through deep phenotyping, characterization of disease heterogeneity, drug discovery, precision medicine, and delivery of clinical care. We discuss the promises and challenges of these technologies and present a vision for their integration into clinical practice.

Keywords:
AutoimmunityBioinformaticsInflammationInflammatory skin diseases

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