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Use of Continuous Glucose Monitoring for Detecting and Understanding Early Dysglycemia in Cystic Fibrosis

Holly Cooper1, Christine L Chan2

  • 1Stanford University School of Medicine, Palo Alto, CA, USA.

Journal of Diabetes Science and Technology
|February 14, 2026
PubMed

Insights

Cystic fibrosis-related diabetes (CFRD) is common in adults with cystic fibrosis (CF). Continuous glucose monitoring (CGM) shows promise for detecting early glucose issues in people with CF (pwCF) before CFRD develops.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Metabolic disorders

Background:

  • Cystic fibrosis-related diabetes (CFRD) affects up to 50% of adults with cystic fibrosis (CF).
  • CFRD is linked to worse lung function, nutrition, and survival in people with CF (pwCF).
  • Prediabetes and hyperglycemia in pwCF precede CFRD diagnosis and are associated with adverse health outcomes.

Purpose of the Study:

  • To review and summarize current literature on continuous glucose monitoring (CGM) in the prediabetic state of pwCF.
  • To highlight research gaps and needs regarding CGM use for early dysglycemia detection in CF.

Main Methods:

  • Literature review of studies utilizing CGM in pwCF with prediabetes.
  • Analysis of CGM data for insights into CFRD pathophysiology and early dysglycemia detection.
  • Synthesis of current evidence on CGM application in CF prediabetes management.

Main Results:

  • CGM is increasingly used in research and clinical settings for CFRD insights.
  • Early glucose abnormalities, including prediabetes, are detectable years before CFRD diagnosis.
  • The use of CGM for early dysglycemia detection in pwCF is growing.

Conclusions:

  • CGM offers valuable insights into glucose metabolism in pwCF.
  • Further research is needed to establish management guidelines for early glucose abnormalities detected by CGM in pwCF.
  • The rising prevalence of CFRD due to increased longevity necessitates improved early detection and management strategies.

Keywords:
continuous glucose monitoringcystic fibrosiscystic fibrosis-related diabetes

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