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Updated: Feb 16, 2026

Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles
Published on: March 15, 2012
Shaping Aspergillus niger into a next-generation cell factory for L-malic acid
He Liu1, Mei-Yi Chang1, Chi Zhang1
1State Key Laboratory of Microbial Technology, Nanjing Normal University, Nanjing, Jiangsu 210000, China; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, Jiangsu 210000, China.
None:
L-Malic acid, a versatile platform chemical, is increasingly manufactured through sustainable microbial fermentation. The filamentous fungus Aspergillus niger stands as a premier cell factory for its industrial production due to its native production capacity and metabolic versatility. This review summarizes cutting-edge advances in elucidating and engineering the L-malic acid biosynthetic pathway in A. niger. A core focus lies on systems metabolic engineering and critical enabling tools that collaboratively redirect carbon flux toward enhanced L-malic acid synthesis. We further discuss enduring challenges in industrial-scale-up, including process intensification and downstream processing, and outline promising future directions that integrate systems biology with innovative bioprocess technologies to advance the economic viability of microbial L-malic acid production.
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