TRPM7 channel-kinase in immunity: new frontiers of an emerging therapeutic target

The cation channel and protein kinase transient receptor potential cation channel subfamily M member 7 (TRPM7) has been linked to immune homeostasis, immune cell signaling and differentiation, and inflammatory diseases. Its importance in guiding ion-mediated cellular responses, funneling discrete kinase signal transduction events, and contributing to complex membrane-localized protein networks positions the channel-kinase as a promising pharmacological target. Diseases with underlying exacerbation of ion-coupled cellular responses are in focus. Undoubtedly, the manifold cells of the immune system undertake a key position in their demand for a smoothly adaptable molecular performance, reacting to incorporate environmental and nutritional triggers to guide diverse cellular states. We here discuss a current view of the molecular principles underlying TRPM7 function in immunity and provide a grasping outlook on open questions and research topics we expect to emerge in the upcoming years, positioning TRPM7 as an unattended player at the forefront of immune regulation.