Related Experiment Video

Updated: Feb 16, 2026

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

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Unraveling novel transposable elements (TEs)-driven gene dysregulation in non-small cell lung cancer (NSCLC) by

Sahadevan Shrinidhi1, R Sagaya Jansi1, Ameer Khusro2

  • 1Department of Bioinformatics, Stella Maris College, Chennai, Tamil Nadu, India.

Computational Biology and Chemistry
|February 14, 2026
PubMed

Insights

Transposable elements (TEs) are mobile DNA sequences implicated in cancer. This study reveals novel TE-driven gene dysregulation mechanisms in non-small cell lung cancer (NSCLC), identifying potential diagnostic and therapeutic targets.

Area of Science:

  • Genomics
  • Molecular Biology
  • Cancer Research

Background:

  • Transposable Elements (TEs) are mobile genomic sequences with the potential to disrupt gene regulation and contribute to tumorigenesis.
  • The role of TEs in non-small cell lung cancer (NSCLC) remains largely unexplored.

Purpose of the Study:

  • To investigate TE-driven gene dysregulation in NSCLC using integrated transcriptomic and TE analysis.
  • To identify specific TEs and associated genes as potential diagnostic markers and therapeutic targets in NSCLC.

Main Methods:

  • Integrated transcriptomic and Transposable Element (TE) analysis.
  • Hierarchical clustering of differentially expressed TEs.
  • Analysis of TE expression and differentially expressed genes.
  • Fusion transcript analysis.
  • Molecular docking of TE-associated proteins.

Main Results:

  • Significant over-representation of LTR1A1 and HERVL18-int, with high expression of LINE and ERV members (e.g., HERVL-int, L1MC5, L1M5) in NSCLC samples.
  • Identification of TE-associated genes involved in cell cycle regulation, genomic stability, and tumor progression.
  • Discovery of unique cancer-specific fusion events and potential oncogenic interactions via molecular docking.

Conclusions:

  • Novel TE-driven mechanisms of gene dysregulation in NSCLC have been uncovered.
  • Specific TEs and associated genes represent potential diagnostic markers and therapeutic targets for NSCLC.
  • Findings provide a framework for future research into the mechanistic and clinical significance of TEs in NSCLC.
Keywords:
Gene DysregulationNSCLCTranscriptomicsTransposable Elements

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