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Updated: Feb 16, 2026
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
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Coagulation factor XI and cardiovascular disease: A complex, cardio-specific conundrum.
Vincent Ten Cate1, Harsini Raaja Sulochana1, Hugo Ten Cate2
1Preventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Computational Systems Medicine, Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Med (New York, N.Y.)
|February 14, 2026
Summary
Coagulation factor XI (FXI) inhibition shows promise for thrombosis but requires further study. Ongoing trials must evaluate both its antithrombotic effects and potential cardiovascular side effects.
Area of Science:
- Cardiovascular Medicine
- Hematology
Background:
- Coagulation factor XI (FXI) is a developing target for treating thrombosis.
- Its role in arterial versus venous thrombosis is under investigation.
Purpose of the Study:
- To evaluate the efficacy of FXI(a) inhibition as an add-on therapy for thrombosis.
- To assess potential off-target cardiovascular effects of FXI inhibition.
Main Methods:
- Review of ongoing clinical trials and existing literature on FXI inhibition.
- Analysis of reported antithrombotic efficacy and cardiovascular outcomes.
Main Results:
- FXI(a) inhibition may be most effective as an add-on therapy for arterial thrombosis.
- Reported cardiovascular effects, such as blood pressure changes and altered cardiac function, are inconsistent.
Conclusions:
- FXI inhibition is a potential therapeutic strategy for thrombosis.
- Further research is needed to confirm efficacy and fully understand cardiovascular safety profiles.
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