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Integrated Deep Learning-Based Intracranial Vessel Wall Imaging with DANTE Preparation: Feasibility and Technical
Pranjal Rai1, Vincent Ern Yao Chan2, John C Benson2
1From the Department of Radiology (P.R., V.E.Y.C., J.C.B., F.E.D., P.M.F., V.M.S., S.A.M., G.B.), Mayo Clinic, Rochester, Minnesota raipranjal2@gmail.com.
AJNR. American Journal of Neuroradiology
|February 14, 2026
Summary
Adding Delay Alternating with Nutation for Tailored Excitation (DANTE) preparation to deep learning-accelerated intracranial vessel wall imaging (IC-VWI) reduced artifacts and improved lumen visualization. However, this enhancement came with a slight decrease in vessel wall depiction.
Area of Science:
- Medical Imaging
- Neuroradiology
- Cardiovascular Imaging
Background:
- Intracranial vessel wall imaging (IC-VWI) is crucial for diagnosing cerebrovascular diseases.
- Deep learning (DL) acceleration improves IC-VWI efficiency.
- Optimizing contrast enhancement and artifact reduction in IC-VWI remains a challenge.
Purpose of the Study:
- To assess the feasibility and performance of incorporating Delay Alternating with Nutation for Tailored Excitation (DANTE) preparation into a DL-accelerated post-contrast T1-SPACE sequence for IC-VWI.
- To evaluate the impact of DANTE preparation on lumen and wall visualization and venous flow artifacts.
Main Methods:
- Retrospective analysis of 35 patients undergoing IC-VWI with and without DANTE preparation.
- Comparison of DL-T1-SPACE with DANTE (T1-SPACEDL+DANTE) versus DL-T1-SPACE (T1-SPACEDL).
- Neuroradiologist scoring of lumen/wall visualization and venous flow artifacts; statistical analysis using CLMMs and Wilcoxon tests.
Main Results:
- T1-SPACEDL+DANTE significantly improved lumen visualization (pooled OR 40.02) compared to T1-SPACEDL.
- T1-SPACEDL+DANTE reduced vessel wall visualization (pooled OR 0.11).
- Venous flow artifacts were significantly reduced across all analyzed venous subsites with DANTE preparation (p<0.001).
Conclusions:
- Integrating DANTE preparation into DL-accelerated IC-VWI enhances lumen depiction and reduces artifacts.
- The technique shows promise for improved assessment of intracranial vasculopathies and aneurysms.
- A minor reduction in wall visualization is an expected trade-off for flow suppression.
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