Related Experiment Video
Updated: Feb 16, 2026

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
Published on: March 15, 2024
Treating CRPS and FNSD in an Adolescent: A Case Study
William S Frye1, Giovanni Cucchiaro2, Kym Householder3
1Johns Hopkins All Children's Hospital, St. Petersburg, United States. Wfrye1@jhmi.edu.
Abstract:
Complex Regional Pain Syndrome (CRPS) is a significantly impairing pain condition that can co-occur with other disorders, including Functional Neurological Symptom Disorder (FNSD). Interdisciplinary interventions augmented with peripheral nerve catheters (PNCs) are gaining attention as effective treatments for CRPS, but their utility in treating comorbid conditions like FNSD remains unclear. This case study presents a 15-year-old female who completed a PNC-augmented interdisciplinary pain program followed by outpatient psychotherapy, providing the first description of this approach for a patient with comorbid CRPS and FNSD and examining its short- and long-term impact. The PNC-augmented CRPS program resulted in resolution of CRPS symptoms and initial improvement in FNSD symptoms. However, functional symptoms returned post-discharge with a different presentation. A subsequent course of psychotherapy was associated with reduced FNSD episode frequency and improved overall functioning. Brief interdisciplinary treatment augmented by PNCs may be beneficial for CRPS; however, it does not appear effective for the long-term treatment of FNSD, which may require psychotherapy and intervention. For patients with comorbid CRPS and FNSD, longer-term interdisciplinary or psychological treatment appears essential to support sustained recovery and functional restoration.
Related Concept Videos
Cognitive Development During Adolescence
Erikson's Theory on Socioemotional Development during Adolescence
Revisionist Views of Adolescent and Adult Cognition
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Case Studies
Imaging Studies I: Kidney, Ureter, and Bladder Studies

