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The alcohol-associated hepatitis treatment landscape
Hanna Blaney1,2, Amon Asgharpour1,2
1Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine.
Current Opinion in Gastroenterology
|February 15, 2026
Summary
New treatments for alcohol-associated hepatitis are emerging, offering hope for improved survival. Research is exploring novel drugs, gut-brain axis manipulation, and liver transplantation for this severe liver disease.
Area of Science:
- Hepatology
- Gastroenterology
- Pharmacology
Background:
- Alcohol-associated hepatitis (AH) is a severe form of alcohol-associated liver disease (ALD) with high mortality.
- Current treatment options for AH have historically been limited, with few therapies demonstrating significant survival benefits.
Purpose of the Study:
- To review recent advances in the treatment of alcohol-associated hepatitis.
- To highlight promising new therapies on the horizon for AH management.
Main Methods:
- Review of current literature on pharmacological agents, gut-brain axis manipulation, and liver transplantation for AH.
- Analysis of ongoing and planned clinical trials for novel AH therapies.
Main Results:
- Several new pharmacological agents (larsucosterol, F-652, INT-787) targeting different mechanisms are under investigation.
- Fecal microbiota transplant and other gut-brain axis interventions show potential.
- Early liver transplantation, including living donor options, offers improved survival for select AH patients.
- Steroid therapy remains a mainstay, with recent studies refining its use (e.g., tapering) to balance efficacy and infection risk.
Conclusions:
- Medical management of AH has seen limited change since the 1970s.
- Promising therapies targeting multiple pathophysiological aspects are advancing, with several in late-stage clinical trials (e.g., larsucosterol, INT-787, F-652).
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