Related Experiment Video

Updated: Feb 16, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

884

Association between baseline prostate MRI PI-RADS classification and risk of Gleason upgrade during active

Shayan Smani1, Nishan Sohoni1, Marcin Miszczyk2,3

  • 1Yale School of Medicine, New Haven, CT, USA.

World Journal of Urology
|February 15, 2026
PubMed
Abstract

Insights

Prostate MRI PI-RADS scores predict Gleason Grade Group (GG) upgrade risk in favorable-risk prostate cancer (PCa) patients on active surveillance (AS). Higher PI-RADS scores (4-5) indicate a greater risk of GG upgrade.

Area of Science:

  • Urology
  • Radiology
  • Oncology

Background:

  • Prostate magnetic resonance imaging (MRI) aids in detecting high-grade prostate cancer (PCa).
  • The predictive value of baseline MRI Prostate Imaging-Reporting and Data System (PI-RADS) scores for favorable-risk PCa managed with active surveillance (AS) remains unclear.

Conclusions:

  • Baseline prostate MRI PI-RADS scores are highly prognostic for GG upgrading in favorable-risk PCa patients on AS.
  • Findings suggest the potential for developing tailored surveillance strategies based on initial MRI results.
Keywords:
Image-guided biopsyMagnetic resonance imagingProstate imaging reporting and data systemProstatic neoplasms

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