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Related Experiment Video

Updated: Feb 17, 2026

MRM Microcoil Performance Calibration and Usage Demonstrated on Medicago truncatula Roots at 22 T
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"Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.

Xiyuan Liu1, Bingdong Chang1, Kayeon Kim2

  • 1Department of Civil and Mechanical Engineering, Technical University of Denmark, Lyngby, Denmark.

Small (Weinheim an Der Bergstrasse, Germany)
|February 15, 2026
PubMed
Summary
This summary is machine-generated.

We developed a MEMS micro-coil for precise neural modulation and imaging. This low-invasive device enables simultaneous micromagnetic neuromodulation and calcium imaging, advancing brain circuit research.

Keywords:
BioMEMSMEMS micro‐coilsneural inhibitionneural interfacestwo‐photon imaging

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Implantable neural interfaces are crucial for neuromodulation but face challenges in precision, invasiveness, and compatibility with in vivo imaging.
  • Existing technologies often obstruct advanced imaging techniques like two-photon microscopy.

Purpose of the Study:

  • To report a novel MEMS-based "tone-arm" micro-coil design for enhanced neural interfacing.
  • To overcome limitations of current neural interfaces, particularly optical obstruction during in vivo imaging.

Main Methods:

  • Designed an 800-µm cantilever micro-coil using numerical modeling for electromagnetic fields, safety, and mechanical stability.
  • Developed a toxic-etchant-free fabrication process for micro-coils compatible with two-photon microscopy.
  • Integrated the micro-coil probe for vertical cortical insertion, minimizing optical obstruction.

Main Results:

  • Achieved a micro-coil with a small cross-section (70 × 86 µm²) and mechanical robustness for brain insertion.
  • Demonstrated >95% imaging field visibility during in vivo studies, overcoming optical obstruction.
  • Verified safe implantation with low probe resistance (2 Ω) and minimal tissue heating (< 0.2°C).

Conclusions:

  • The MEMS micro-coil platform enables simultaneous micromagnetic neuromodulation and subcellular-resolution calcium imaging.
  • This technology opens new avenues for dissecting neural circuit dynamics during targeted interventions.
  • The developed device offers a promising tool for potential treatments of neurological disorders like hyperactivity-driven conditions.