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A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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Ischemic stroke and intracranial large-artery disease risk in familial hypercholesterolemia: A prospective Japanese

Yorito Hattori1, Kotaro Noda2, Mika Hori3

  • 1Department of Neurology, National Cerebral and Cardiovascular Center, 6-1, Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan; Department of Preemptive Medicine for Dementia, National Cerebral and Cardiovascular Center, 6-1, Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.

Atherosclerosis
|February 15, 2026
PubMed

Insights

Familial hypercholesterolemia (FH) significantly increases stroke risk and intracranial artery stenosis in Japanese patients. Early detection and intervention are crucial for stroke prevention in at-risk populations.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Genetics

Background:

  • Dyslipidemia's role in stroke is often underestimated compared to hypertension and diabetes.
  • Asian populations exhibit higher susceptibility to intracranial major artery stenosis (ICAS).
  • Familial hypercholesterolemia (FH) may disproportionately impact stroke risk in Asian individuals.

Purpose of the Study:

  • To evaluate the prevalence and incidence of symptomatic ischemic stroke and ICAS in Japanese patients with FH.
  • To compare stroke and ICAS rates in FH patients versus individuals in a brain screening program.

Main Methods:

  • Prospective longitudinal study design.
  • Inclusion of FH patients from a lipid clinic and individuals from a brain screening program (Brain Dock).
  • Brain magnetic resonance imaging (MRI) utilized for all participants.

Main Results:

  • FH identified as an independent risk factor for ICAS (≥50%) with a high odds ratio (17.82).
  • FH patients showed a significantly higher incidence of symptomatic ischemic stroke (aHR: 5.83).
  • ICAS presence strongly correlated with symptomatic ischemic stroke in FH patients (aHR: 7.73).

Conclusions:

  • FH is associated with elevated risk of symptomatic ischemic stroke and intracranial arterial changes in Japanese individuals.
  • Findings underscore the need to consider ethnic and genetic factors in stroke prevention.
  • Targeted screening and management of FH may be vital for reducing stroke burden in susceptible populations.
Abstract

Keywords:
Familial hypercholesterolemiaIntracranial major artery stenosisStroke

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