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Updated: Jul 25, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
Simulation and experimental study on temperature control in perivascular magnetic induction hyperthermia based on
Zhuoyang Li1, Yanyong Ye1, Xin Fu2
1South China University of Technology, Guangzhou, 510000, China.
Abstract:
To address uneven temperature distribution from vascular cooling in liver tumor magnetic hyperthermia, this study proposes a clinically oriented zonal control strategy using magnetic media with distinct Curie temperatures (66 °C and 75 °C). By constructing a Multiphysics coupled model of a liver tumor with a Y-shaped vascular structure, and validating the model's effectiveness through ex vivo tissue experiments, we simulated the temperature field distribution under alternating magnetic fields. Additionally, we analyzed the effects of blood flow velocity, vascular bifurcation angle, and vessel diameter on the surrounding tissue temperature. The results demonstrate that this strategy enables precise thermal ablation in the tumor core (up to 71.7 °C) while maintaining safe temperatures in perivascular regions (∼38.5 °C) and achieving effective hyperthermia at the tumor margin (43 °C). The study confirms that magnetic field intensity has a dominant influence over frequency in temperature elevation. This approach provides a theoretical and experimental basis for developing targeted and safe hyperthermia in highly vascularized tumors, overcoming the challenge of vascular heat dissipation.
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