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Association between left ventricular end-diastolic volume and cardiovascular disease in systemic hypertensive

Sharezhati Yishajiang1, Qing Zhu1, Delian Zhang1

  • 1Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China; Xinjiang Hypertension Institute, Urumqi, China; NHC Key Laboratory of Hypertension Clinical Research, Urumqi, China; Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory", Urumqi, China; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China.

Sleep Medicine
|February 15, 2026
PubMed

Insights

Elevated left ventricular end-diastolic volume (LVEDV) significantly increases cardiovascular disease (CVD) risk in patients with systemic hypertension and obstructive sleep apnea (OSA). Routine LVEDV assessment aids in identifying high-risk individuals for timely preventive strategies.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Echocardiography

Background:

  • Systemic hypertension and obstructive sleep apnea (OSA) are prevalent conditions independently linked to increased cardiovascular disease (CVD) risk.
  • Left ventricular end-diastolic volume (LVEDV) is a key echocardiographic measure of cardiac remodeling.
  • The prognostic significance of LVEDV in patients with both hypertension and OSA is not well-established.

Purpose of the Study:

  • To investigate the association between baseline LVEDV and the incidence of CVD.
  • To determine if LVEDV can serve as a prognostic biomarker in patients with coexisting systemic hypertension and OSA.

Main Methods:

  • Retrospective cohort study of 1914 patients with confirmed systemic hypertension and OSA.
  • Patients stratified into tertiles based on baseline LVEDV.
  • Multivariable Cox proportional hazards models used to assess CVD risk, adjusted for covariates.

Main Results:

  • Higher LVEDV tertiles correlated with increased CVD incidence over a median follow-up of 83 months.
  • The highest LVEDV tertile (>81 mL) showed a significantly elevated CVD risk (HR=1.86, P=0.001) compared to the lowest tertile (<70 mL).
  • Associations remained significant across sensitivity and stratified analyses.

Conclusions:

  • Elevated LVEDV is an independent predictor of CVD in patients with systemic hypertension and OSA.
  • LVEDV is a valuable, easily obtainable echocardiographic biomarker for cardiovascular risk stratification in this population.
  • Routine LVEDV assessment can facilitate early identification of high-risk individuals and guide preventive interventions.
Abstract

Keywords:
Cardiovascular diseaseLeft ventricular end-diastolic volumeObstructive sleep apneaSystemic hypertension

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