Death Following Percutaneous Coronary Intervention: Data From the PROGRESS-COMPLICATIONS Registry.

Area of Science:

• Cardiology
• Interventional Cardiology
• Clinical Outcomes

Background:

• Percutaneous coronary intervention (PCI) related mortality remains understudied.
• Understanding PCI-related deaths is crucial for improving patient outcomes.
• Limited data exists on the characteristics and causes of mortality following PCI.

Purpose of the Study:

• To investigate the incidence, characteristics, and causes of mortality associated with percutaneous coronary intervention (PCI).
• To identify risk factors and clinical presentations associated with PCI-related death.
• To analyze the primary drivers of mortality in patients undergoing PCI.

Main Methods:

• Analysis of 22,503 patients undergoing PCI from the PROGRESSCOMPLICATIONS registry.
• Examination of patient demographics, comorbidities, lesion complexity, and procedural details.
• Categorization of mortality causes, including periprocedural, early, and late post-PCI deaths.

Main Results:

• Overall PCI-related mortality was 0.5% (115 deaths).
• Deaths were more frequent in patients with complex coronary lesions and acute presentations (NSTEMI/STEMI).
• Cardiogenic shock was the primary cause of death (80.9%), often linked to acute myocardial infarction and requiring left ventricular assist device (LVAD) support.

Conclusions:

• Periprocedural death after PCI occurs in 0.5% of cases, particularly with complex lesions and acute presentations.
• Cardiogenic shock is the leading cause of death post-PCI.
• High rates of LVAD use were observed in patients who died from cardiogenic shock.