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Updated: Jun 14, 2026

Studying Neurobehavioral Effects of Environmental Pollutants on Zebrafish Larvae
Published on: February 5, 2020
Neurobiology and neuropharmacology of zebrafish social behavior
Kirill V Apukhtin1, Vyacheslav D Riga1,2,3, Maria M Kotova1
1Neurobiology Program, Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Federal Territory Sirius, Russia.
Abstract:
A popular model organism for studying neural and molecular mechanisms of behavior, the zebrafish (Danio rerio) displays a wide range of robust and quantifiable social phenotypes, including shoaling/schooling, social preference and learning, as well as aggression and mating behaviors. Zebrafish social behavior is influenced by various neurotransmitters and hormones (including serotonin, dopamine, isotocin, cortisol, and endocannabinoids) and can be modulated experimentally, including genetically and pharmacologically. Here, we summarize current knowledge on neurobiology and neuropharmacology of zebrafish social behavior, and discuss various effects of drugs and other manipulations that target this critical behavioral domain.
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