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Updated: Feb 17, 2026
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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Exposure to GLP-1RA and Risk of Structural Progression in Differentiated Thyroid Cancer.
Armando Patrizio1,2, Audrey Mauguen3, James A Fagin1
1Department of Medicine, Endocrinology Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA.
The Journal of Clinical Endocrinology and Metabolism
|February 16, 2026
Summary
Glucagon-like peptide-1 receptor agonists (GLP-1RA) did not increase the risk of differentiated thyroid cancer (DTC) recurrence or progression. Patients with DTC can safely use GLP-1RA for cardiometabolic benefits when indicated.
Area of Science:
- Endocrinology
- Oncology
- Metabolic Diseases
Background:
- Glucagon-like peptide-1 receptor agonists (GLP-1RA) are beneficial for diabetes mellitus (DM) and obesity.
- GLP-1RA are contraindicated in medullary thyroid cancer.
- The impact of GLP-1RA on differentiated thyroid cancer (DTC) is not well understood.
Purpose of the Study:
- To investigate the association between GLP-1RA use and the risk of recurrence or progression in patients with DTC.
Main Methods:
- Retrospective observational cohort study.
- Matched 1:1 cohort of 1072 patients with DTC (536 exposed to GLP-1RA, 536 unexposed).
- Multi-state model to assess GLP-1RA impact on disease recurrence/progression.
Main Results:
- GLP-1RA use was not significantly associated with DTC recurrence or progression in survival (HR=0.87) or entire cohorts (HR=0.75).
- Multivariable models adjusted for age, ATA risk, radioactive iodine therapy, and DM.
- Median follow-up was 69 months with median GLP-1RA exposure of 16 months.
Conclusions:
- No significant association found between GLP-1RA use and recurrent/progressive DTC.
- Patients with DTC should not be denied cardiometabolic benefits of GLP-1RA if clinically indicated.
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