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Elucidation of Enhanced Lysine Sensing via Pt-Functionalized 2D WS2 for Biosensing Applications
Jisang Yoo1, Iaan Cho1, Sangyoon Lee1
1School of Electrical and Electronic Engineering, Yonsei University, Seodaemun-Gu, Seoul 03722, South Korea.
ACS Applied Materials & Interfaces
|February 16, 2026
Summary
Platinum nanoparticles enhance tungsten disulfide biosensors for sensitive lysine detection. This advancement improves disease diagnosis by enabling more accurate identification of lysine levels.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Amino acids (AAs) are crucial biomarkers for disease diagnosis.
- Lysine (LYS) is vital for protein synthesis, and its abnormal levels indicate various health disorders.
- Two-dimensional transition metal dichalcogenides (2D TMDCs) offer potential for label-free biosensing due to direct charge transfer.
Purpose of the Study:
- To enhance the sensitivity and selectivity of 2D TMDC-based biosensors for lysine detection.
- To investigate the effect of platinum nanoparticle (Pt NP) functionalization on monolayer WS2 (1L-WS2) biosensing performance.
- To explore the interaction mechanisms between functionalized WS2 and lysine using experimental and computational methods.
Main Methods:
- Functionalization of 1L-WS2 with Pt NPs using atomic layer deposition (ALD).
- Fabrication and characterization of Pt-functionalized WS2 (Pt-WS2) biosensors.
- Performance evaluation of Pt-WS2 and pristine WS2 biosensors for LYS detection.
- Density functional theory (DFT) calculations to analyze adsorption energy and charge transfer.
Main Results:
- Pt NP functionalization induced n-type doping in WS2, enhancing its sensitivity to LYS.
- Pt NPs with (111) facets facilitated stronger interactions with LYS molecules.
- Pt-WS2 biosensors demonstrated significantly improved sensitivity and selectivity for LYS detection compared to pristine WS2.
- DFT calculations confirmed increased LYS adsorption energy and charge transfer on Pt-WS2.
Conclusions:
- Metal nanoparticle functionalization is an effective strategy to boost the performance of 2D TMDC biosensors.
- Pt-WS2 biosensors show great promise for accurate and sensitive detection of lysine for disease diagnosis.
- This approach advances the practical application of 2D TMDC-based biosensing platforms.
